Abstract Distinct neurodevelopmental disorders have a common genetic etiology that explains the high degree of comorbidity among these disorders.A recent study sought to identify copy number variants across Clips five neurodevelopmental disorders, and detected an enrichment for chromosome 9p24.3 duplication encompassing DOCK8 and KANK1 in affected
Abstract Background Osteosarcoma is highly malignant.The migration, invasion, and chemoresistance contribute to poor prognosis of osteosarcoma.Research reported that endogenous bornavirus-like nucleoprotein 3 pseudogene (EBLN3P) promotes the progression of osteosarcoma.Methods In this study, the expression of EBLN3P in osteosarcoma tissue with diff
Abstract To understand the origin and early evolution of life it is crucial to establish characteristics of the primordial environment that facilitated the emergence and evolution of life.One important environmental factor is the pH Clips of the primordial environment.Here, we assessed the pH-dependent thermal stabilities of previously reconstructe
Keratinocytes are the first cells that come into direct contact with external tactile stimuli; however, their role in touch transduction in vivo is not clear.The ion channel Transient Receptor Potential Ankyrin 1 (TRPA1) is essential for some mechanically-gated currents in sensory neurons, amplifies mechanical responses after inflammation, and has